myHealthScore | Polygenic Risk screening

myHealthScore

Polygenic risk screening for common diseases

myHealthScore is a genetic test that provides information about a patient’s risk of common multifactorial diseases. The test analyzes polygenic risk providing detection for a larger number of people.

What is polygenic risk?

The most common diseases are often multifactorial in origin meaning that they are caused by the effect of genetics together with other factors such as lifestyle and environment.

In these cases, the genetic risk is not usually associated with a single variant but with thousands or even millions of common variants throughout the genome. This is known as a polygenic risk.

Who is it intended for?

The test is suitable for adults who are proactive about their healthcare. The results provide information about the lifetime risk of presenting the diseases analysed in order to establish preventive strategies and lifestyle changes that will help to reduce the risk.

Additionally, a basic ancestry analysis is completed to adjust the risk analysis based on the patient’s genealogy.

Which diseases are included in myHealthScore?

Cardiovascular disease*

>2 millions variants

Type 2 diabetes

> 600,000 variants

Breast cancer

> 550,000 variants

Prostate cancer

> 650,000 variants

myHealthScore is available for cardiovascular disease, type 2 diabetes and cancer risk.

*For a more comprehensive analysis of cardiovascular disease, the test includes the polygenic risk of: coronary artery disease, atrial fibrillation, lipid profile (triglycerides, LDL and HDL cholesterol) and hypertension.

Whole genome sequencing technology and analysis with CE-IVD software.
Analysis of thousands to millions of variants related to the conditions tested.
Possibility of extending the assay to other conditions as the science advances.
Access to Veritas calculator to assess the absolute risk based on genetic and clinical factors.

Advantages of myHealthScore

The software for the analysis is CE-marked and enables the risk evaluation of presenting different pathologies, providing the specialist with important information for your healthcare:

Cardiovascular disease: The test enables the reclassification of patients with intermediate risk by classical factors who, depending on their genes, could present high risk of coronary artery disease.

Type 2 diabetes: A nutritional or pharmacological approach in high-risk patients could avoid the development of the disease.

Breast cancer: The test allows the detection of polygenic risk of breast cancer in women that is not detectable by other genetic tests. These cases are usually considered to be of sporadic origin.

Prostate cancer: myHealthScore is a valuable tool for the screening of this type of cancer, where current strategies have limitations.

Are you interested in myHealthScore but you do not have a prescribing doctor?

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Why is myHealthScore important?

Allows the quantification of the aggregated genetic risk, scattered along the genome, associated with a particular disease.
The test is performed once in a lifetime, estimating the risk of disease and how it varies throughout life in comparison with the general population.
It can be carried out before the onset of clinical risk factors, which allows for a more effective preventive approach.
There are calculators that establish the risk of cardiovascular disease and cancer. Incorporating myHealthScore results into these calculators improves their predictive power. Veritas provides physicians access to the risk calculators for cardiovascular disease and breast cancer.
•Information that is independent and complementary to traditional risk factors and the study of genetic panels.

1 out of every 4 people with coronary artery disease is undetected through the evaluation of clinical risk factors.

7 out of every 10 women diagnosed with breast cancer do not have a family history of the disease.

8 out of 10 people with pre-diabetes are not aware of their condition and the possibilities for prevention.

Poligenic risk calculators

If you have already taken the myHealthScore test you can broaden the scope of your results by considering your polygenic risk index along with other biomarkers. Find out how through our calculators:

Coronary Artery Disease Risk Calculator

Breast cancer risk assessment calculator